Coexistence of insulin induced acanthosis and lipoatrophy in a patient with type 1 DM
نویسندگان
چکیده
Localized acanthosis nigricans at the insulin injection site is a rare skin disorder in patients with diabetes mellitus. We report co-existence of acanthosis nigricans and lipoatrophy at injection sites in the same patient with type 1 DM. A 23 year old male patient with a history type 1 DM for 11 years was admitted to hospital due to recurrent diabetic ketoacidosis attacks. There were two lesions over the abdominal skin which occurred due to repeated insulin injection at the same sites. Despite structured and continuous education even in developed countries, poor injection technique still remains a challenging factor in uncontrolled diabetes mellitus. Injection sites should be checked for localized acanthosis nigricans in addition to
منابع مشابه
Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity.
We describe the clinical features of 28 patients with juvenile dermatomyositis (JDM) and 1 patient with adult-onset dermatomyositis (DM), all of whom developed lipodystrophy (LD) that could be categorized into 1 of 3 phenotypes, generalized, partial, or focal, based on the pattern of fat loss distribution. LD onset was often delayed, beginning a median of 4.6 years after diagnosis of DM. Calcin...
متن کاملSyndrome of Extreme Insulin Resistance (Rabson-Mendenhall Phenotype) with Atrial Septal Defect: Clinical Presentation and Treatment Outcomes
Syndrome of extreme insulin resistance (SEIR) is a rare spectrum disorder with a primary defect in insulin receptor signalling, noted primarily in children, and is often difficult to diagnose due to the clinical heterogeneity.SEIR was diagnosed in an adolescent girl with facial dysmorphism,exuberant scalp and body hair, severe acanthosis, lipoatrophy, dental abnormalities, and short stature (Ra...
متن کاملDetemir plus aspart and glulisine induced lipoatrophy: 2015 literature review and report of a new case
BACKGROUND In the first and only literature review, conducted in 2009, of human insulin analog- induced lipoatrophy, there were 12 published cases, including 1 with aspart, 1 with detemir, 1 with NovoMix 30 and none with detemir plus aspart. It is perceived that insulin analog induced-lipoatrophy is increasing. We conducted a 2015 literature review of published reports of lipoatrophy induced by...
متن کاملA Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy
ZMPSTE24 encodes the only metalloprotease, which transforms prelamin into mature lamin A. Up to now, mutations in ZMPSTE24 have been linked to Restrictive Dermopathy (RD), Progeria or Mandibulo-Acral Dysplasia (MAD). We report here the phenotype of a patient referred for severe metabolic syndrome and cardiomyopathy, carrying a mutation in ZMPSTE24. The patient presented with a partial lipodystr...
متن کاملComparison of Insulin resistance in obese women with and without Acanthosis Nigricans
Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of AN. In this study insulin resistance was compared in obese women with and without AN.</sp...
متن کامل